The molecular physiology of CRH neurons
نویسندگان
چکیده
منابع مشابه
Molecular evolution of GPCRs: CRH/CRH receptors.
Corticotrophin-releasing hormone (CRH) is the pivotal neuroendocrine peptide hormone associated with the regulation of the stress response in vertebrates. However, CRH-like peptides are also found in a number of invertebrate species. The origin of this peptide can be traced to a common ancestor of lineages leading to chordates and to arthropods, postulated to occur some 500 million years ago. E...
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All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these programmes must be sufficiently flexible to account for changes in the environment. Here we show that hypothalamic CRH neurons orchestrate an environmentally flexible repertoire of behaviours that emerge after acute stress in mice. Optical silencing of CRH...
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p0005 Corticotropin-releasing hormone [CRH; also referred to as corticotropin-releasing factor (CRF)] is a member of a family of related peptides in vertebrates that includes the fish urotensins-I, frog sauvagine, and the urocortin/stresscopin peptides. CRF was first named for its stimulatory effect on corticotropin [also known as adrenocorticotropic hormone (ACTH)] secretion from the anterior ...
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Corticotropin-releasing hormone (CRH), with widespread expression in the brain, plays a key role in modulating a series of behaviors, including anxiety, arousal, motor function, learning and memory. Previous studies have focused on some brain regions with densely distributed CRH neurons such as paraventricular hypothalamic nucleus (PVH) and bed nuclei of the stria terminalis (BST) and revealed ...
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ژورنال
عنوان ژورنال: Frontiers in Neuroendocrinology
سال: 2012
ISSN: 0091-3022
DOI: 10.1016/j.yfrne.2011.08.002